胡正教授
胡正，吉林大学第一医院，教授，博士生导师，入选国家高层次青年人才；任吉林大学器官再造与移植教育部重点实验室副主任，免疫学研究所副主任。中国科学技术大学本科(2005)、博士(2010)，中国科学技术大学/美国哈佛大学医学院MGH联合培养博士(2008-2011)，美国哥伦比亚大学博士后(2011-2013)。主要研究领域包括：人源化动物模型、人类细胞/器官再造与异种移植、免疫调节与转化免疫；获得中科院A类先导专项、国家自然科学基金重点项目、面上项目等项目资助；以第一作者或通讯作者在Blood, Cell Mol Immunol, Stem Cell Reports, J Immunol, Transplantation等杂志发表论文20余篇，共发表SCI论文28篇，被引用900余次；获吉林省科技成果转化贡献奖（2021年），吉林省自然科学一等奖（2022年；第三完成人）。
研究方向：
（1）人源化小鼠疾病动物模型研究：研发细胞、组织、器官高度人源化的小鼠模型，准确模拟人类疾病发生和药物/疗法临床前评价。
（2）人源化猪生物反应器研究：研发具有人类细胞、器官高水平嵌合的人源化猪生物反应器，实现人类细胞产品规模化制备，及人源功能器官的制造
（3）移植免疫及异种器官移植研究：研究同种异体及异种细胞/器官移植排斥的基本规律，研发基因编辑猪器官异种移植新策略。
发表论文：
1.Macrophages prevent human red blood cell reconstitution in immunodeficient mice.Hu Z, Van Rooijen N, Yang YG.Blood2011 Nov 24;118(22):5938-46
2.Full reconstitution of human platelets in humanized mice after macrophage depletion.Hu Z, Yang YG.Blood.2012 Aug 23;120(8):1713-6.
3.Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34(+) cells.Hu Z, Yang YG.Cell Mol Immunol.2012 May;9(3):232-6.
4.An effective approach to prevent immune rejection of human ESC-derived allografts.Rong Z, Wang M,Hu Z, Stradner M, Zhu S, Kong H, Yi H, Goldrath A, Yang YG, Xu Y, Fu X.Cell Stem Cell.2014 Jan 2;14(1):121-30.
5.Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice.Hu Z, Xia J, Fan W, Wargo J,Yang YG.Oncotarget.2016 Feb 9;7(6):6448-59.
6.Type 1 diabetes induction in humanized mice. Tan S, Li Y, Xia J, Jin CH,Hu Z, Duinkerken G, Li Y, Khosravi Maharlooei M, Chavez E, Nauman G, Danzl N, Nakayama M, Roep BO, Sykes M, Yang YG.Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10954-10959.
7.Complement depletion improves human red blood cell reconstitution in immunodeficient mice. Chen B,Fan W, Zhang SW, He J, Shu C,Zhao GQ,Sun TM,Hu Z*, Yang YG*.Stem Cell Reports.2017 Oct 10;9(4):1034-1042.
8.Antithymocyte globulin treatment at the time of transplantation impairs donor hematopoietic stem cell engraftment. Jin F, He J, Jin C, Fan W, Shan Y, Zhang Z, Sun L,Hu Z*, Yang YG*.Cell Mol Immunol,2017 May;14(5):443-450
9.Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes. Zhou T, Wang G*, Lyu Y, Wang L, Zuo S, Zou J, Sun L, Zhao W, Shu C, Yang YG,Hu Z*.Cell Death Dis. 2019 Jul 22;10(8):559.
10.Long-term survival and differentiation of human thymocytes in human thymus-grafted immunodeficient mice. Tang Y, Yang YG, Bai O, Xia J,Hu Z*. Immunotherapy. 2019 Jul;11(10):881-888. doi: 10.2217/imt-2019-0030.
11.IL2RG-deficient minipigs generated via CRISPR/Cas9 technology support the growth of human melanoma-derived tumours. Ren J, Yu D, Fu R, An P, Sun R, Wang Z, Guo R, Li H, Zhang Y, Li Z, Yang YG, Li W, Hai T*,Hu Z*. Cell Prolif. 2020 Oct;53(10):e12863.
12.Generation of GGTA1-/-β2M-/-CIITA-/-pigs using CRISPR/Cas9 technology to alleviate xenogeneic immune reactions, Fu R, Fang MH, Xu K, Ren JL, Zou J, Su L, Chen XX, An PP, Yu DW, Ka MN, Hai T, Li ZY, Li W, Yang YG, Zhou Q*,Hu Z*; Transplantation, 2020 Aug;104(8):1566-1573.
13.Humanized mice reveal an essential role for human hepatocytes in the development of the liver immune system. Guo J, Li Y, Shan Y, Shu C, Wang F, Wang X, Zheng G, He J,Hu Z*, Yang YG*.Cell Death Dis. 2018 Jun 4;9(6):667.
14.Incompatibility between recipient CD47 and donor SIRPα is not a key risk factor for thrombocytopenia or anemia following rat liver xenotransplantation in mice.Li T, Lv Y, Sun R, Yang YG,Hu Z*, Lv G*. Xenotransplantation. 2020 Oct 28:e12657
15.Humanized Rodent Models for Cancer Research. Tian H, Lyu Y, Yang YG,Hu Z*. Front Oncol. 2020 Sep 11;10:1696.
16.Role of CXCR4 in the progression and therapy of acute leukaemia, Su L,Hu Z*, Yang YG*,Cell Prolif, 2021 Jul;54(7):e13076.
17.Posttransplant blockade of CXCR4 improves leukemia complete remission rates and donor stem cell engraftment without aggravating GVHD. Su L, Fang MH, Zou J, Gao SJ, Gu XY, Meng XD, Wang X,Hu Z*, Yang YG*. Cell Mol Immunol. 2021 Nov;18(11):2541-2553
18.Exploration of Human Lung-Resident Immunity and Response to Respiratory Viral Immunization in a Humanized Mouse Model. Wang Y, Wang L, Fu C, Wang X, Zuo S, Shu C, Shan Y, He J, Zhou Q, Li W, Yang YG*,Hu Z*, Hua S*. J Immunol. 2022 Jan 15;208(2):420-428.
19.Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver. Jilong Ren#, Dawei Yu#, Jing Wang#, Kai Xu#, Yanan Xu, Renren Sun, Peipei An, Chongyang Li, Guihai Feng, Ying Zhang, Xiangpeng Dai, Hongye Zhao, Zhengzhu Wang, Zhiqiang Han, Haibo Zhu, Yuchun Ding, Xiaoyan You, Xueqin Liu, Meng Wu, Lin Luo, Ziyi Li, Yong-Guang Yang,Zheng Hu*, Hong-Jiang Wei*, Liangpeng Ge*, Tang Hai*, Wei Li* Cell Biosci. 2022 Mar 7;12(1):26.
20.Uterine Natural Killer Cells: A Rising Star in Human Pregnancy Regulation. Xie M, Li Y, Meng YZ, Xu P, Yang YG, Dong S, He J,Hu Z. Front Immunol. 2022 Jun 1;13:918550. doi: 10.3389/fimmu.2022.918550.
21.Improvement of human myeloid and natural killer cell development in humanized mice via hydrodynamic injection of transposon plasmids containing multiple human cytokine genes. Tan S, Fang M, Fan W, Wang Z, Lv Y, Zou J, Wang X, Liu B, Yang YG,Hu Z. Immunol Cell Biol. 2022 Jun 4.
22.Humanized mice for investigating SARS-CoV-2 lung infection and associated human immune responses. Sun R, Zhao Z, Fu C, Wang Y, Guo Z, Zhang C, Liu L, Zhang C, Shu C, He J, Yang YG, Hua S, Gao Y,Hu Z. Eur J Immunol. 2022 Oct;52(10):1640-1647.
